The effectiveness of the steroid ciclesonide against asthma as an outpatient treatment for patients with symptoms of COVID

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Outpatient symptomatic COVID-19 patients who were treated with ciclesonide for early symptom relief saw no difference in results compared to patients who were treated with a placebo of the drug.

Outpatient symptomatic COVID-19 patients who were treated with ciclesonide for early symptom relief saw no difference in results compared to patients who were treated with a placebo of the drug.

In a randomized, double-blind clinical trial, 400 patients from 10 different centers in the United States were screened in the trial from June 11, 2020 to November 3, 2020, according to a JAMA Internal Medicine study.

Patients who had symptoms related to COVID (cough, dyspnea, chills, feeling feverish, repeated tremors accompanied by chills, muscle pain, headache, sore throat, and new loss of taste or smell) were tested to see if the inhaled steroid for asthma has been detected. in common brands like Zetonna and Alvesco, would relieve symptoms as early as 30 days.

The secondary outcome of the clinical trial was to test whether ciclesonide plus standard supportive care reduced the incidence of emergency department visits or hospitalizations for COVID-19-related reasons compared to placebo plus standard supportive care. standard support.

Among the included and randomized patients (197 in the ciclesonide arm and 203 in the placebo arm), the median time to improvement of all symptoms related to COVID-19 was 19 days in the ciclesonide arm and 19 days. in the placebo arm.

There was no difference in resolution of all symptoms by day 30, but participants who were treated with ciclesonide had fewer subsequent emergency room visits or hospitalizations for COVID-19-related reasons. No participant died during the study.

The results of the study suggest that future studies of inhaled steroids are needed to explore efficacy in patients at high risk of disease progression and to reduce the incidence of long-term symptoms of COVID-19.


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